abstract：:Immunization against the most common meningeal pathogens is the leading factor associated with decreased incidence of bacterial meningitis in countries where routine vaccination is available. This is most dramatically illustrated by the reduction in the incidence of Haemophilus influenzae type b meningitis. The incide...

journal_title：Current infectious disease reports

authors： Dery MA,Hasbun R

更新日期：2007-07-01 00:00:00

abstract：:Treatment of chronic rhinosinusitis still represents an unmet medical need. Presently, the US Food and Drug Administration has not approved any drugs for the treatment of this common condition. Various inflammatory processes are involved in the pathogenesis of chronic rhinosinusitis. Treatment of infection and surgica...

journal_title：Current infectious disease reports

authors： Hatipo U,Rubinstein I

更新日期：2007-05-01 00:00:00

abstract：:Two million of the 15 million (13.3%) new cases of sexually transmitted infections (STIs) among persons 15 to 49 years old occur in pregnant women. Access to care and a provider's ability to assess risk, screen, and treat STIs are critical factors in preventing adverse pregnancy outcomes. Significant variations in pro...

journal_title：Current infectious disease reports

authors： Johnson HL,Erbelding EJ,Ghanem KG

更新日期：2007-03-01 00:00:00

abstract：:Although mixed infections are known to be clinically relevant in conditions such as nosocomial pneumonia and ventilator-related pneumonia, it is increasingly recognized that a substantial number of community-acquired lower respiratory tract infections may also be attributed to more than one pathogenic organism. A bett...

journal_title：Current infectious disease reports

authors： Tarsia P,Aliberti S,Pappalettera M,Blasi F

更新日期：2007-01-01 00:00:00

abstract：:Urinary tract infection (UTI) is a common clinical syndrome in women. Most UTIs are caused by Escherichia coli. UTI has become a productive and accessible model system for studying the molecular details of how bacteria interact with mucosal surfaces and the nature of the host response. Important advances in the past y...

journal_title：Current infectious disease reports

authors： Stapleton AE

更新日期：2006-11-01 00:00:00

abstract：:The ability to predict efficacy and toxicity during antiretroviral therapy for HIV would be of obvious advantage. The substantial variability between patients in terms of bioavailability and distribution of current regimens is likely driven by genetic and environmental factors. Protease inhibitors and nucleoside/nucle...

journal_title：Current infectious disease reports

authors： Owen A

更新日期：2006-09-01 00:00:00

abstract：:Endocarditis pathogens colonize valves with pre-existing sterile vegetations or valves with minimal endothelial lesions. Inflamed endothelia produce cytokines, integrins, and tissue factor, which in turn attract fibronectin, monocytes, and platelets. Bacteria attaching to such structures further activate the cascade, ...

journal_title：Current infectious disease reports

authors： Widmer E,Que YA,Entenza JM,Moreillon P

更新日期：2006-06-01 00:00:00

abstract：:Acute otitis media (AOM), when associated with a bulging or full tympanic membrane, has a bacterial etiology in more than 90% of cases. Not infrequently, the organisms present express resistance mechanisms to commonly prescribed antibiotic therapy. Tympanocentesis is a procedure advocated by several national guideline...

journal_title：Current infectious disease reports

authors： Pichichero ME,Wright T

更新日期：2006-05-01 00:00:00

abstract：:Neisseria gonorrhoeae is a common cause of genitourinary sexually transmitted infections. N. gonorrhoeae is an obligate human pathogen that has evidence of tissue-specific host interactions and diverse extragenital manifestations of infection both in adult and pediatric populations. The clinical presentation of extrag...

journal_title：Current infectious disease reports

authors： Spencer SE,Bash MC

更新日期：2006-03-01 00:00:00

abstract：:Eosinophilia in patients exposed to tropical or subtropical environments is caused most commonly by helminth (worm) infections. Besides a detailed exposure history, the diagnostic approach must consider other infections and noninfectious causes of eosinophilia, as treatments for many of these disorders differ. ...

journal_title：Current infectious disease reports

authors： Kim YJ,Nutman TB

更新日期：2006-01-01 00:00:00

abstract：:Candida species are an important cause of health care-related bloodstream infections (BSI). Understanding the current Candida BSI incidence trends, the dominant species causing disease, and the mortality associated with this infection are important to help guide therapeutic and prophylaxis measures. In this review, tr...

journal_title：Current infectious disease reports

authors： Morgan J

更新日期：2005-11-01 00:00:00

abstract：:Patients with sepsis may require mechanical ventilation due to the acute respiratory distress syndrome (ARDS). It has become increasingly accepted that mechanical ventilation can contribute to lung injury in these patients. The modern concept of ventilator-induced lung injury is described in the context of alveolar ov...

journal_title：Current infectious disease reports

authors： Hess DR,Thompson BT

更新日期：2005-09-01 00:00:00

abstract：:Bacterial meningitis is a complex disorder in which neurologic injury is caused, in part, by the causative organism and, in part, by the host's own inflammatory response. In studies of experimental bacterial meningitis, adjuvant treatment with corticosteroids, specifically dexamethasone, has beneficial effects. On the...

journal_title：Current infectious disease reports

authors： van de Beek D,de Gans J

更新日期：2005-07-01 00:00:00

abstract：:A variety of antigen-capture assays are commercially available for the detection of influenza. In addition, real-time multiplex polymerase chain reaction (PCR) has been used to detect influenza A and B in clinical specimens. The commercial assays can be completed in less than 30 minutes and have a sensitivity of at le...

journal_title：Current infectious disease reports

authors： Pachucki CT

更新日期：2005-05-01 00:00:00

abstract：:High-risk human papillomaviruses (HPVs) are now recognized as the etiologic agents of invasive cervical cancer, a major cancer in women. A single HPV type (type 16) is responsible for about 50% of the cancers. The major capsid protein of papillomaviruses, L1, when expressed by recombinant DNA technology, has the intri...

journal_title：Current infectious disease reports

authors： Gravitt PE,Shah KV

更新日期：2005-03-01 00:00:00

abstract：:Neurocysticercosis, caused by infection with the pork tapeworm Taenia solium, is increasingly recognized as a cause of neurologic disease worldwide. Because the clinical presentation is nonspecific, diagnosis has been difficult. Advances in imaging studies and serodiagnostic techniques are facilitating the diagnosis o...

journal_title：Current infectious disease reports

authors： Yancey LS,Diaz-Marchan PJ,White AC

更新日期：2005-01-01 00:00:00

abstract：:Colonization with Staphylococcus aureus is a risk factor for invasive S. aureus infections. Intranasal mupirocin has effectively eradicated S. aureus colonization and appears to prevent S. aureus nosocomial infections in some patient populations. In hospitals and communities where mupirocin use has been widespread, re...

journal_title：Current infectious disease reports

authors： Polgreen PM,Herwaldt LA

更新日期：2004-12-01 00:00:00

abstract：:Arthroplasty of the knee and hip is a common procedure. There is a risk of infection with primary arthroplasty, with an incidence of 1% to 2%. Significant cost and morbidity are associated with infection of the prosthetic joint. Most infections (60% to 70%) are caused by staphylococci, but approximately 10% are caused...

journal_title：Current infectious disease reports

authors： Lentino JR

更新日期：2004-10-01 00:00:00

abstract：:Transmissible spongiform encephalopathies (TSEs) are a group of progressive, fatal neurodegenerative disorders that share a common spongiform histopathology. TSEs may be transmitted in a sporadic, familial, iatrogenic, or zoonotic fashion. The putative infectious agent of TSE, the prion, represents a novel paradigm of...

journal_title：Current infectious disease reports

authors： Janka J,Maldarelli F

更新日期：2004-08-01 00:00:00

abstract：:This article reviews techniques of rapid testing and the effective diagnosis of streptococcal pharyngitis. Despite 50 years' study of streptococcal pharyngitis and 20 years' experience with rapid tests for its diagnosis, the subject continues to evolve. Rapid diagnostic tests have become more sensitive. Experts now co...

journal_title：Current infectious disease reports

authors： Corneli HM

更新日期：2004-06-01 00:00:00

abstract：:Skin lesions provide an important clue to the diagnoses of many infections in returned travelers. New information related to epidemiology, recognition, diagnosis, or management is described for the systemic infections--dengue fever, several of the rickettsial infections, African trypanosomiasis, and coccidioidomycosis...

journal_title：Current infectious disease reports

authors： Wilson ME,Chen LH

更新日期：2004-02-01 00:00:00

abstract：:The pathogenesis of vulvovaginal candidiasis, which is caused by Candida albicans, is poorly understood. Despite a strong protective role for cell-mediated immunity (CMI) against other mucosal candidal infections, numerous studies in humans and most animal models have revealed little to no role for CMI or other forms ...

journal_title：Current infectious disease reports

authors： Fidel PL

更新日期：2003-12-01 00:00:00

abstract：:Although waterborne pathogens are relatively uncommon causes of cutaneous infections, these agents are being recognized with increasing frequency. Humans are exposed to water through a variety of recreational and occupational activities. Poor sanitary conditions in developing nations place the human populations at con...

journal_title：Current infectious disease reports

authors： Elko L,Rosenbach K,Sinnott J

更新日期：2003-10-01 00:00:00

abstract：:Although modern medicine has improved survival in congenital heart disease dramatically, the long-term course carries a risk of late complications. The incidence of infective endocarditis in adults with congenital heart disease is more than 10 times higher than that of the normal population. Identification of the high...

journal_title：Current infectious disease reports

authors： Thilén U

更新日期：2003-08-01 00:00:00

abstract：:Increases in sexually transmitted diseases (STDs) among men who have sex with men (MSM) have coincided with recent increases in sexual risk behaviors across the United States and Europe. The identification of same-sex sexual risk behavior in men and the subsequent risk for certain bacterial and viral infections requir...

journal_title：Current infectious disease reports

authors： Klausner JD,Wong W

更新日期：2003-04-01 00:00:00

abstract：:Malaria is a devastating disease, inflicting epidemic morbidity and mortality with an estimated 500 million cases and 2.5 million deaths annually. Children suffer the most severe morbidity; one child dies of malaria every 30 seconds, accounting for over 1 million of the deaths annually. There continues to be a tremend...

journal_title：Current infectious disease reports

authors： Stauffer WM,Kamat D

更新日期：2003-02-01 00:00:00

abstract：:The dogma is that the higher risk of pyelonephritis in pregnant women is explained entirely by anatomic/obstructive changes. If so, gestational pyelonephritis should be caused by random, nonpathogenic bacteria. Instead, gestational pyelonephritis is associated with a narrow group of genetically related Escherichia col...

journal_title：Current infectious disease reports

authors： Nowicki B

更新日期：2002-12-01 00:00:00

abstract：:Skin and soft tissue infections vary widely in their nature and severity, and their nomenclature is complex. Most are readily recognized and easily treated, but more severe infections may masquerade in forms similar to those of more innocent infections, causing delay in diagnosis and treatment that may result in loss ...

journal_title：Current infectious disease reports

authors： Alam MR,Hershberger E,Zervos MJ

更新日期：2002-10-01 00:00:00

abstract：:Therapy of cryptococcal meningitis has been focused primarily on optimizing the antifungal regimen to improve the previously high treatment failure rates. Until recently, relatively little attention has been paid to the impact of increased intracranial pressure, which is a frequent problem that complicates management ...

journal_title：Current infectious disease reports

authors： Gambarin KJ,Hamill RJ

更新日期：2002-08-01 00:00:00

abstract：:Fungi are common inhabitants of the oral and nasal mucosa, and therefore the differentiation between colonization and pathogenicity in the setting of upper respiratory tract infection symptoms can be difficult. Fungal head and neck infections occur in both immunocompetent and immunocompromised persons, and patients wi...

journal_title：Current infectious disease reports

authors： Miller DJ

更新日期：2002-06-01 00:00:00

abstract：:Heavily pretreated HIV-infected patients with multidrug-resistant virus remain a clinical challenge to the treating physician. While the goal of therapy in such patients is still controversial, sustained immunologic and clinical benefit have only been demonstrated with complete suppression of plasma viral load below d...

journal_title：Current infectious disease reports

authors： Montaner JS,Harris M

更新日期：2002-06-01 00:00:00

abstract：:Hepatic failure due to hepatitis C is the leading indicator for orthotopic liver transplantation (OLT) in the United States. Unfortunately, recurrent hepatitis C virus infection is essentially universal following orthotopic liver transplantation. Although significant advances have been made in the past decade for the ...

journal_title：Current infectious disease reports

authors： A Bobak D,Yadavalli G

更新日期：2002-04-01 00:00:00

abstract：:Although highly active antiretroviral therapy suppresses HIV replication resulting in extraordinary clinical benefits, toxicity, adherence difficulties, and the monetary cost of medications limit the long-term effectiveness and availability of therapy for many HIV-infected individuals. Strategies to interrupt therapy ...

journal_title：Current infectious disease reports

authors： Dybul M

更新日期：2002-04-01 00:00:00

abstract：:Diarrhea is one of the most common health problems among travelers. Although enterotoxigenic Escherichia coli is implicated most commonly, enteroaggregative E. coli has recently been described as a major pathogen. Shigella, Campylobacter, and Salmonella organisms are less common causes of acute diarrhea, and intestina...

journal_title：Current infectious disease reports

authors： Cheng AC,Thielman NM

更新日期：2002-02-01 00:00:00

abstract：:Urinary tract infections are common, especially among women, and cause significant morbidity. While prognosis is probably more dependent on whether or not an episode of urinary tract infection is complicated (ie, associated with functional, metabolic, or anatomic abnormalities of the urinary tract) or uncomplicated, a...

journal_title：Current infectious disease reports

authors： Zandi-Nejad K,Brown PD

更新日期：2001-12-01 00:00:00

abstract：:Many data associate low protease inhibitor plasma concentrations with suboptimal virologic responses, whereas relatively few data associate high plasma concentrations with increased likelihood of toxicity. Knowledge of relationships between concentrations and virologic response is important because significant variabi...

journal_title：Current infectious disease reports

authors： Anderson PL,Fletcher CV

更新日期：2001-08-01 00:00:00

abstract：:Although most cases of rhinosinusitis are benign, the disruption of quality of life due to disease symptoms leads patients to seek early medical care. Ongoing debates dispute the definition, bacteriology, and medical management of chronic sinusitis, while the criteria for acute sinusitis are relatively well establishe...

journal_title：Current infectious disease reports

authors： Hadley JA

更新日期：2001-06-01 00:00:00

abstract：:Pulmonary nocardiosis is an uncommon but serious infection that is increasingly found in immunosuppressed persons, especially transplant recipients and persons with AIDS. The Nocardia species are denizens of soil and decaying plants that gain entry to humans through inhalation or inoculation. Pulmonary nocardiosis typ...

journal_title：Current infectious disease reports

authors： Baracco GJ,Dickinson GM

更新日期：2001-06-01 00:00:00

abstract：:Clostridium difficile is a major cause of antibiotic-associated diarrhea. While treatment regimens for C. difficile have been available for decades, they remain less than optimal due to the frequent recurrences that occur after therapy is completed. Moreover, the morbidity and expense associated with C. difficile have...

journal_title：Current infectious disease reports

authors： Ciesla WP,Bobak DA

更新日期：2001-04-01 00:00:00

abstract：:With the causal link between specific types of human papillomavirus (HPV) and cervical cancer firmly established, efforts have turned to assessing the relative merits of offering HPV testing in screening, triage, and posttreatment management. Many unanswered questions remain, but a growing body of evidence supports a ...

journal_title：Current infectious disease reports

authors： Kulasingam SL,Koutsky LA

更新日期：2001-04-01 00:00:00